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The Dickey laboratory then used an aerosolized Edition inside of a mouse product to verify the drug diminished mucin secretion and airway blockage by mucus. Importantly, SP9 didn't influence the sluggish-launch pathway for ordinary mucin secretion.
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"We constructed up an image of what the secretory equipment looked like and we realized each of the major players," Dickey said. "After we had an concept of how many of the pieces labored together, we decided synaptotagmin-2 (Syt2) was the top protein to focus on to block mucin secretion as it only becomes activated by using a high amount of stimulation.
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